| Vendredi 22 octobre 2021 | ||||||
|---|---|---|---|---|---|---|
| 20:45 | FC Seraing | 13 | Sporting de Charleroi | Comparer | ||
| Samedi 23 octobre 2021 | ||||||
| 16:15 | CS Bruges | 11 | Standard | Comparer | ||
| 18:30 | FC Malines | Zulte-Waregem | Comparer | |||
| 18:30 | Courtrai | Ostende | Comparer | |||
| 20:45 | Eupen | Royale Union Saint-Gilloise | Comparer | |||
| Dimanche 24 octobre 2021 | ||||||
| 13:30 | Antwerp | FC Bruges | Comparer | |||
| 16:00 | Anderlecht | Beerschot | Comparer | |||
| 18:30 | Genk | La Gantoise | Comparer | |||
| 21:00 | Oud-Heverlee Leuven | St-Trond | Comparer | |||
| Pts | Jou. | Gag. | Per. | Nuls | Pou. | Con. | Diff. | ||
|---|---|---|---|---|---|---|---|---|---|
| 1. | Royale Union Saint-Gilloise | 22 | 11 | 7 | 3 | 1 | 24 | 11 | + 13 |
| 2. | FC Bruges | 22 | 11 | 6 | 1 | 4 | 20 | 13 | + 7 |
| 3. | Eupen | 20 | 11 | 6 | 3 | 2 | 21 | 14 | + 7 |
| 4. | Antwerp | 20 | 11 | 6 | 3 | 2 | 21 | 15 | + 6 |
| 5. | Sporting de Charleroi | 20 | 12 | 5 | 2 | 5 | 22 | 14 | + 8 |
| 6. | FC Malines | 19 | 11 | 6 | 4 | 1 | 19 | 19 | 0 |
| 7. | Genk | 17 | 11 | 5 | 4 | 2 | 21 | 17 | + 4 |
| 8. | Ostende | 17 | 11 | 5 | 4 | 2 | 16 | 19 | -3 |
| 9. | Anderlecht | 17 | 11 | 4 | 2 | 5 | 21 | 14 | + 7 |
| 10. | Courtrai | 15 | 11 | 4 | 4 | 3 | 14 | 14 | 0 |
| 11. | St-Trond | 15 | 11 | 4 | 4 | 3 | 12 | 14 | -2 |
| 12. | Standard | 15 | 12 | 4 | 5 | 3 | 13 | 20 | -7 |
| 13. | La Gantoise | 14 | 11 | 4 | 5 | 2 | 18 | 13 | + 5 |
| 14. | FC Seraing | 12 | 12 | 4 | 8 | 0 | 16 | 24 | -8 |
| 15. | Zulte-Waregem | 12 | 11 | 3 | 5 | 3 | 17 | 24 | -7 |
| 16. | Oud-Heverlee Leuven | 10 | 11 | 1 | 3 | 7 | 11 | 19 | -8 |
| 17. | CS Bruges | 9 | 12 | 2 | 7 | 3 | 13 | 19 | -6 |
| 18. | Beerschot | 2 | 11 | 0 | 9 | 2 | 7 | 23 | -16 |
