| Vendredi 22 octobre 2021 | ||||||
|---|---|---|---|---|---|---|
| 20:45 | FC Seraing | 13 | Sporting de Charleroi | Comparer | ||
| Samedi 23 octobre 2021 | ||||||
| 16:15 | CS Bruges | 11 | Standard | Comparer | ||
| 18:30 | FC Malines | 22 | Zulte-Waregem | Comparer | ||
| 18:30 | Courtrai | 10 | Ostende | Comparer | ||
| 20:45 | Eupen | 23 | Royale Union Saint-Gilloise | Comparer | ||
| Dimanche 24 octobre 2021 | ||||||
| 13:30 | Antwerp | 11 | FC Bruges | Comparer | ||
| 16:00 | Anderlecht | 42 | Beerschot | Comparer | ||
| 18:30 | Genk | 03 | La Gantoise | Comparer | ||
| 21:00 | Oud-Heverlee Leuven | 41 | St-Trond | Comparer | ||
| Pts | Jou. | Gag. | Per. | Nuls | Pou. | Con. | Diff. | ||
|---|---|---|---|---|---|---|---|---|---|
| 1. | Royale Union Saint-Gilloise | 25 | 12 | 8 | 3 | 1 | 27 | 13 | + 14 |
| 2. | FC Bruges | 23 | 12 | 6 | 1 | 5 | 21 | 14 | + 7 |
| 3. | Antwerp | 21 | 12 | 6 | 3 | 3 | 22 | 16 | + 6 |
| 4. | Eupen | 20 | 12 | 6 | 4 | 2 | 23 | 17 | + 6 |
| 5. | FC Malines | 20 | 12 | 6 | 4 | 2 | 21 | 21 | 0 |
| 6. | Anderlecht | 20 | 12 | 5 | 2 | 5 | 25 | 16 | + 9 |
| 7. | Sporting de Charleroi | 20 | 12 | 5 | 2 | 5 | 22 | 14 | + 8 |
| 8. | Courtrai | 18 | 12 | 5 | 4 | 3 | 15 | 14 | + 1 |
| 9. | La Gantoise | 17 | 12 | 5 | 5 | 2 | 21 | 13 | + 8 |
| 10. | Genk | 17 | 12 | 5 | 5 | 2 | 21 | 20 | + 1 |
| 11. | Ostende | 17 | 12 | 5 | 5 | 2 | 16 | 20 | -4 |
| 12. | St-Trond | 15 | 12 | 4 | 5 | 3 | 13 | 18 | -5 |
| 13. | Standard | 15 | 12 | 4 | 5 | 3 | 13 | 20 | -7 |
| 14. | Zulte-Waregem | 13 | 12 | 3 | 5 | 4 | 19 | 26 | -7 |
| 15. | Oud-Heverlee Leuven | 13 | 12 | 2 | 3 | 7 | 15 | 20 | -5 |
| 16. | FC Seraing | 12 | 12 | 4 | 8 | 0 | 16 | 24 | -8 |
| 17. | CS Bruges | 9 | 12 | 2 | 7 | 3 | 13 | 19 | -6 |
| 18. | Beerschot | 2 | 12 | 0 | 10 | 2 | 9 | 27 | -18 |