| Vendredi 15 octobre 2021 | ||||||
|---|---|---|---|---|---|---|
| 20:45 | FC Bruges | 20 | Courtrai | Comparer | ||
| Samedi 16 octobre 2021 | ||||||
| 16:15 | Royale Union Saint-Gilloise | 42 | FC Seraing | Comparer | ||
| 18:30 | Zulte-Waregem | 21 | Antwerp | Comparer | ||
| 18:30 | Ostende | 21 | CS Bruges | Comparer | ||
| 20:45 | Standard | 22 | Oud-Heverlee Leuven | Comparer | ||
| Dimanche 17 octobre 2021 | ||||||
| 13:30 | St-Trond | Anderlecht | Comparer | |||
| 16:00 | Beerschot | FC Malines | Comparer | |||
| 18:30 | Sporting de Charleroi | Genk | Comparer | |||
| 21:00 | La Gantoise | Eupen | Comparer | |||
| Pts | Jou. | Gag. | Per. | Nuls | Pou. | Con. | Diff. | ||
|---|---|---|---|---|---|---|---|---|---|
| 1. | Royale Union Saint-Gilloise | 22 | 11 | 7 | 3 | 1 | 24 | 11 | + 13 |
| 2. | FC Bruges | 22 | 11 | 6 | 1 | 4 | 20 | 13 | + 7 |
| 3. | Eupen | 20 | 10 | 6 | 2 | 2 | 21 | 12 | + 9 |
| 4. | Antwerp | 20 | 11 | 6 | 3 | 2 | 21 | 15 | + 6 |
| 5. | Genk | 17 | 10 | 5 | 3 | 2 | 21 | 15 | + 6 |
| 6. | Ostende | 17 | 11 | 5 | 4 | 2 | 16 | 19 | -3 |
| 7. | FC Malines | 16 | 10 | 5 | 4 | 1 | 18 | 19 | -1 |
| 8. | Anderlecht | 16 | 10 | 4 | 2 | 4 | 19 | 12 | + 7 |
| 9. | Courtrai | 15 | 11 | 4 | 4 | 3 | 14 | 14 | 0 |
| 10. | St-Trond | 14 | 10 | 4 | 4 | 2 | 10 | 12 | -2 |
| 11. | Standard | 14 | 11 | 4 | 5 | 2 | 12 | 19 | -7 |
| 12. | Sporting de Charleroi | 14 | 10 | 3 | 2 | 5 | 17 | 13 | + 4 |
| 13. | FC Seraing | 12 | 11 | 4 | 7 | 0 | 15 | 21 | -6 |
| 14. | Zulte-Waregem | 12 | 11 | 3 | 5 | 3 | 17 | 24 | -7 |
| 15. | La Gantoise | 11 | 10 | 3 | 5 | 2 | 16 | 13 | + 3 |
| 16. | Oud-Heverlee Leuven | 10 | 11 | 1 | 3 | 7 | 11 | 19 | -8 |
| 17. | CS Bruges | 8 | 11 | 2 | 7 | 2 | 12 | 18 | -6 |
| 18. | Beerschot | 2 | 10 | 0 | 8 | 2 | 7 | 22 | -15 |
